What does the claustrum do?

Here with colleagues from physiology, we review the clinical effects of damage to the claustrum in Atilgan et al. Brain (2022). The claustrum is a thin sheet of neurons in the frontal lobe. Very few reported cases have isolated claustrum damage. In those who did, the findings don’t clearly reflect what you might expect, given the known fMRI activations and connections of the claustrum.